Thymocyte Selection and Activation Lck and Erk Activities and Influences Constitutively Active Protein Kinase B Enhances
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چکیده
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Constitutively Active Lck Kinase in T Cells Drives Antigen Receptor Signal Transduction
T cell antigen receptor (TCR) and coreceptor ligation is thought to initiate signal transduction by inducing activation of the kinase Lck. Here we showed that catalytically active Lck was present in unstimulated naive T cells and thymocytes and was readily detectable in these cells in lymphoid organs. In naive T cells up to approximately 40% of total Lck was constitutively activated, part of wh...
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